Blood test for enzyme deficiency G6PD - Private

A large part of the population lives regularly with an enzyme deficiency G6PD, the widespread stigma is that it is a "disease that is actually an allergy to beans" but is it anaphylaxis? Can adrenaline help? Why Iraqis?

Physiological basis: the enzyme G6PD Found in all the cells in the body, the cells require oxygen regularly and in order to prevent oxygen damage we have the enzyme G6PD whose role is to protect against oxidative damage caused by metabolism, hence a lack of that enzyme will cause damage to the cells that carry the oxygen - to the red blood cells to the point of destruction.

missing in G6PD: Lack G6PD It is the most common human enzyme defect observed in over 400 million people worldwide. It is a hereditary disease that passes through the sex chromosomeXIt means that men have onlyXsingle (men =XY) are more likely to get sick than women (who haveXXSo even ifXOne carrying the missing will still be a chromosomeXAnother that will prevent the manifestation of the disease so that the woman will mainly be a carrier and pass the disease on but will not get sick herself unless in the 2ndXShe has the disease (but it is already related to genetics and less to our subject) the patients are usually without special symptoms but in stress and stress situations or in situations of exposure to certain drugs that contain free radicals or foods that contain these substances such as Paul, what happens during exposure is that there is a harmful substance In a body that there is no one to protect us from, in normal condition eG6PDHelps in the creation of anti-oxidant substances, but now there are no such substances due to the deficiency in the enzyme, therefore there will be a breakdown of the oxygen-carrying red blood cells.

In whom is it common? to lack b G6PD There are about 200 different types of mutations, among the main mutations is the one known as  G6PDMediterranean: which is the type that is most common among Jews of Kurdistan origin (where the frequency of the defect is the highest and may reach up to 50% of men), Iraq, as well as among the Muslim concentration in Lebanon. The mutation is less common among Greeks, Turkish Italians, North Africans, Sephards, Portuguese or Ashkenazi Jews. This mutation is manifested in the hemolysis caused by eating pulses (fava beans), as well as in the hemolytic disease in newborns - so that even a child who is born and develops signs of hemolysis (details below) may be diagnosed with a deficiency in G6PD.

Hemolysis: also called blood dissolution, is a condition in which the red blood cells are broken down, as a result of which hemoglobin is released into the plasma liquid. Hemolysis occurs naturally in the spleen, where about 1 percent of all red blood cells in the body are broken down each day. In certain pathological conditions, the blood cells are destroyed in an unnatural way. These conditions may lead to anemic hemolysis

What can cause hemolysis - destruction of blood cells in patients with B deficiency G6PD? There are various medicines and foods that contain free radicals that cause cells to be destroyed, among the medicines you can find aspirin which is prohibited only in high doses (lack ofG6PDnot defined as a contraindication in the case of a cardiac event, in which case the aspirin dose of 160-325 mg is still defined as a low dose) you can also find Silverol on the list - a common ointment for burns, pain medications, vitaminCIn high doses, various antibiotics and more, it is important to note that the list of drugs that are prohibited for patients with B deficiencyG6PDIt is updated and changes over time according to studies and tests of the health systems in Israel and around the world. Also, eating pulses may trigger hemolysis in these patients.

The signs of hemolysis: in general, when a person with a lack of bG6PDWhen exposed to medicine or pulses (and this can also be when inhaling pulse vapors while cooking or passing through a field of pulses), hemolysis begins - the breakdown of blood cells which usually does not cause a real risk, but in cases of more significant exposure there may also be a more serious reaction, meaning increased destruction of blood cells. The signs can be divided into 2 subgroups:

Signs related to the destruction of red blood cells and the decrease in the ability to carry oxygen in the body, so there may be signs of weakness, dizziness, paleness and signs of lack of blood.

Signs related to the content of the blood corpuscles - when a red cell is destroyed and all its contents remain in the blood fluid, because of the large amount of iron and hemoglobin accumulated in the blood fluid, it is more difficult for the liver to clear them from the body and thus jaundice is actually formed (the hemoglobin is broken down in the spleen and eventually turns into bilirubin which is the substance that comes out on the skin in jaundice) together On top of that, there are additional substances in the bloodstream that may cause other damages besides jaundice, it is important to emphasize that such jaundice in newborns can be life-threatening

Therefore, the treatment of the patient with hemolysis is divided into 2: At first, blood doses will be given in order to restore what has already been destroyed (the doses will contain the enzyme G6PD Because otherwise the blood cells in the portion will also be destroyed) and if the body will not be able to remove all the accumulated waste materials - and in fact the body will not cope well with the jaundice, the patient will also have to undergo temporary dialysis treatments.

In fact, the best treatment is avoiding prohibited substances and eating pulses. In most cases, a person with a deficiency will be able to go through his life without special problems and without the need for special monitoring. In the case of an acute multi-crisis, it is necessary to be hospitalized and monitor the hemoglobin level, as well as monitor the activity of the kidneys. In most cases, there is no danger to the patient's life under appropriate treatment and the events pass quickly. If necessary, blood transfusions can be used to raise the hemoglobin level or dialysis to treat and protect the kidneys.

In summary: Paul and substances and drugs containing free radicals may cause hemolysis in patients with B deficiency G6PD and for signs of blood destruction and not for signs of allergy, hence it is not a normal allergy that reacts to adrenaline and therefore you should not use an epifene syringe when exposed to Paul, an anamnesis should be performed directed at the family background and find out whether it is an allergy or a deficiency in G6PD. Although it is important and mandatory to emphasize that patients with a deficiency in G6PD are still entitled to be sensitive to various substances regardless of their lack, so the treatment is yes with epiphane according to need,   and therefore here too an open mind and a deliberate anamnesis can help us understand what the patient in front of us is suffering from.

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We perform a G6PD test, you can contact us to perform the test.
There is no need for a doctor's referral.